SOURCE-LINKED STUDY SUMMARY
Prolonged tadalafil exposure promotes skeletal muscle myogenesis and regulates early myogenic markers activation in C2C12 cell lines.
Abstract summarizedQuality not appraised
- What was studied
- A cell-culture study tested prolonged tadalafil exposure during early muscle-cell development.
- Who / model studied
- C2C12 mouse myoblast cultures, not people or an in-vivo hypertrophy trial.
- Studied dose & schedule
- Cells received 1 µM tadalafil for up to seven days.
- What the study found
- Proliferation and survival increased, but terminal differentiation was delayed and mature multinucleated myotubes decreased. Early myogenic markers increased while myostatin and TGFβ decreased.
- Limitations & context
- Abstract-based assessment. More proliferating cells do not establish larger or stronger muscles. Culture concentrations cannot be translated directly into human doses; clinical efficacy and safety were not tested.
Read summary source ↗ · Prepared 10/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1007/s11033-026-12929-x