SOURCE-LINKED STUDY SUMMARY
Betaine supplementation modulates mitochondrial and redox-related adaptations in premenopausal women with overweight: a randomized controlled trial.
Abstract summarizedQuality not appraised
- What was studied
- A randomized trial examined blood-cell mitochondrial and antioxidant markers.
- Who / model studied
- Premenopausal women with overweight or obesity; sample size not specified in the abstract.
- Studied dose & schedule
- Anhydrous betaine 3 g/day versus placebo for eight weeks.
- What the study found
- Citrate-synthase protein concentration changed by 102.3 μg/mg protein more than placebo (95% CI 3.19–201.4), despite nonsignificant within-group changes. Catalase activity increased; other measured mitochondrial/redox markers did not clearly improve.
- Limitations & context
- Blood-cell protein concentration is not muscle mitochondrial function, ATP production or hypertrophy. Clinical significance remains unresolved. Abstract assessment; adverse-event counts unavailable.
Read summary source ↗ · Prepared 10/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1007/s00394-026-04131-3