Postoperative outcomes after total knee arthroplasty in type 2 diabetes mellitus patients receiving semaglutide versus tirzepatide: a propensity score-matched national research network analysis.

Studied

A retrospective comparison of short-term outcomes after knee replacement among people prescribed semaglutide versus tirzepatide.

Who / model

Adults with type 2 diabetes undergoing knee replacement were matched into 415 pairs. Outcomes were tracked through 90 and 180 days.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

The groups had no statistically clear differences in overall medical complications by 90 days, surgical complications by 180 days, individual listed events, emergency visits or readmissions.

Limits

This prescription-based observational comparison cannot establish equal safety in all surgical patients. Several outcomes were uncommon, reducing precision.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary