Increased Energy Expenditure through Intermittent Cold Exposure Does Not Enhance Tirzepatide Induced Weight-loss in Obese Mice.

Studied

An experiment tested whether intermittent cold exposure added to tirzepatide's effects on weight and blood-sugar regulation.

Who / model

Male and female mice received a high-fat diet for eight weeks, then tirzepatide or vehicle, with or without cold exposure, for three weeks. The abstract does not state the number of mice.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Tirzepatide reduced weight, food intake and body fat in both sexes. Cold exposure briefly increased energy use and improved blood-sugar regulation without weight changes. Combining them produced no additional effects.

Limits

Study limitations were not stated in the abstract. Methodological quality has not been appraised.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary