SOURCE-LINKED STUDY SUMMARY
The Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging.
Full paper summarizedQuality not appraised
- What was studied
- Researchers reanalyzed muscle epigenetic clocks after NR supplementation and high-intensity interval training in separate studies.
- Who / model studied
- Human skeletal-muscle samples from three independent NR and exercise studies; complementary cultured human muscle-cell experiments.
- Studied dose & schedule
- NR for 5 months, reaching 1000 mg/day; separate HIIT interventions lasted 4-6 weeks.
- What the study found
- NR lowered estimated age acceleration on some clocks, while HIIT changed some clocks in the opposite direction. Results depended on the clock used.
- Limitations & context
- No placebo controls or randomized NR-versus-exercise comparison. Small, heterogeneous cohorts and surrogate clocks cannot establish lifespan effects or that exercise accelerates harmful aging.
Read summary source ↗ · Prepared 10/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: full paper. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1111/acel.70638