SOURCE-LINKED STUDY SUMMARY
A cross-species atlas of the dorsal vagal complex reveals neural mediators of the effects of cagrilintide on energy balance.
Abstract summarizedQuality not appraised
- What was studied
- This mechanistic study mapped brainstem cells across species and tested which neuronal populations mediate cagrilintide's effects on energy balance in rats, rather than testing human clinical efficacy.
- Who / model studied
- The atlas included over 530,000 cells and 80 neuronal populations from rats, mice, and macaques. Functional treatment experiments were in rats; animal sample sizes were not stated.
- Studied dose & schedule
- Researchers examined acute and long-term cagrilintide exposure, neuronal activation, and suppression of Prlh expression, with semaglutide as a comparison in suppression experiments. Doses, route, frequency, and exact durations were not reported.
- What the study found
- Activating area-postrema neurons did not change long-term food intake or weight. Long-term cagrilintide increased Prlh expression in another neuronal population. Suppressing Prlh abolished cagrilintide's effects but not semaglutide's in rats.
- Limitations & context
- Study limitations were not stated in the abstract. Methodological quality has not been appraised.
Read summary source ↗ · Prepared 9/24/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1038/s42255-026-01539-3