SOURCE-LINKED STUDY SUMMARY
A cross-species atlas of the dorsal vagal complex reveals neural mediators of the effects of cagrilintide on energy balance.
What was studied?
This mechanistic study mapped brainstem cells across species and tested which neuronal populations mediate cagrilintide's effects on energy balance in rats, rather than testing human clinical efficacy.
What changed?
Activating area-postrema neurons did not change long-term food intake or weight. Long-term cagrilintide increased Prlh expression in another neuronal population. Suppressing Prlh abolished cagrilintide's effects but not semaglutide's in rats.
Who was studied?
The atlas included over 530,000 cells and 80 neuronal populations from rats, mice, and macaques. Functional treatment experiments were in rats; animal sample sizes were not stated.
Studied exposure
Researchers examined acute and long-term cagrilintide exposure, neuronal activation, and suppression of Prlh expression, with semaglutide as a comparison in suppression experiments. Doses, route, frequency, and exact durations were not reported.
What remains uncertain?
Study limitations were not stated in the abstract. Methodological quality has not been appraised.
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1038/s42255-026-01539-3