Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis.

Studied

A double-blind randomized trial tested weekly semaglutide plus lifestyle counseling versus placebo for obesity with painful knee osteoarthritis.

Who / model

Participants had obesity, radiologically confirmed moderate knee osteoarthritis, and at least moderate pain.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Semaglutide produced greater reductions in body weight and WOMAC pain than placebo by the end of treatment.

Limits

Permanent treatment discontinuation was more frequent with semaglutide, most commonly because of gastrointestinal disorders.

Read summary source ↗ · Prepared 9/16/2026 · AI-assisted, source-based summary