Pharmacotherapy of obesity: an update on the available medications and drugs under investigation.

Studied

Evidence review of approved anti-obesity medicines and investigational drugs, updating prior work with Medline and Embase searches.

Who / model

The review included 46 randomized trials and 8 systematic reviews or meta-analyses of adults with obesity, plus ongoing adult pipeline trials.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Available medicines improved weight and metabolic measures with differing potency. At the review date, evidence did not show reduced hard cardiovascular outcomes, and long-term mortality data remained scarce.

Limits

Searches covered selected date windows and the pipeline search was updated through June 4, 2022. This synthesis is not one comparative trial, and the authors emphasized scarce long-term outcome evidence.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary