SOURCE-LINKED STUDY SUMMARY
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Full paper summarizedQuality not appraised
- What was studied
- Tested whether oral nicotinamide riboside changes skeletal-muscle NAD+ metabolism, mitochondrial bioenergetics and inflammatory signaling in older adults.
- Who / model studied
- Twelve older men completed a randomized, double-blind, placebo-controlled crossover trial.
- Studied dose & schedule
- Participants received oral NR at 1 g/day for 21 days and placebo in crossover periods.
- What the study found
- NR increased markers of the muscle NAD+ metabolome and lowered circulating inflammatory cytokines, but did not alter mitochondrial bioenergetics.
- Limitations & context
- This short study enrolled only older men and measured metabolic and transcriptomic signals rather than patient-important clinical outcomes, so functional benefit remains unproven.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: full paper. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1016/j.celrep.2019.07.043