SOURCE-LINKED STUDY SUMMARY
Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study.
Abstract summarizedQuality not appraised
- What was studied
- This phase II randomized trial tested whether bimagrumab could increase thigh muscle volume and improve physical function in older adults with sarcopenia and mobility limitations.
- Who / model studied
- Forty community-dwelling adults were at least sixty-five years old and had both low appendicular muscle mass and impaired walking speed.
- Studied dose & schedule
- Participants received one intravenous comparison of bimagrumab at thirty milligrams per kilogram or placebo; the source did not report repeated administration.
- What the study found
- Thigh muscle volume increased early, remained above baseline through follow-up and exceeded placebo. Among slower walkers, gait speed and six-minute walk distance also improved.
- Limitations & context
- Not all randomized participants completed follow-up, and mobility findings emphasized a baseline subgroup. Muscle symptoms, acne and diarrhea were mostly mild and resolved.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1111/jgs.14927